By Stefan H. E. Kaufmann, Bruce D. Walker
Offering the newest details on preventive, diagnostic and healing features of tuberculosis and AIDS, this can be the one publication to put an important emphasis at the expanding coexistence of those life-threatening ailments in individuals.
Edited by way of awesome scientists within the box, this prepared reference is split into 3 major sections overlaying immunology and vaccination concepts, medicines, and scientific issues.
well timed analyzing for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, in addition to for the pharmaceutical and biotechnological industries.
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Extra info for AIDS and Tuberculosis: A Deadly Liaison
And Okuda, K. (2001) A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeﬁciency virus. Hum. , 12, 1047–1061. , Poirier, A. R. (1999) Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model. J. , 73, 8549–8558. R. R. (2000) Selective Rep-Cap gene ampliﬁcation as a mechanism for high-titer recombinant AAV production from stable cell lines. Mol. , 2, 394–403. O. C. (2007) Recombinant adeno-associated virus vectors induce functionally impaired transgene product-speciﬁc CD8 þ T cells in mice.
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The characteristic feature of the adeno-associated virus is a deﬁciency in replication, and thus its inability to multiply in unaffected cells. However, new AAV particles are successfully generated in the presence of selected proteins derived from the adenovirus genome , or other viruses such as HSV . Although recombinant AAV (rAAV) vectors have been initially developed for gene replacement therapy, several characteristics have made these potential candidates for vaccine delivery : (i) rAAV vectors are well tolerated; (ii) they fail to induce strong vector-directed inﬂammatory responses, although the induction of neutralizing antibodies has been described ; and (iii) rAAV vectors do not introduce any of their viral genes into the host cells.