AIDS and Tuberculosis: A Deadly Liaison by Stefan H. E. Kaufmann, Bruce D. Walker

By Stefan H. E. Kaufmann, Bruce D. Walker

Offering the newest details on preventive, diagnostic and healing features of tuberculosis and AIDS, this can be the one publication to put an important emphasis at the expanding coexistence of those life-threatening ailments in individuals.
Edited by way of awesome scientists within the box, this prepared reference is split into 3 major sections overlaying immunology and vaccination concepts, medicines, and scientific issues.
well timed analyzing for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, in addition to for the pharmaceutical and biotechnological industries.

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And Okuda, K. (2001) A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus. Hum. , 12, 1047–1061. , Poirier, A. R. (1999) Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model. J. , 73, 8549–8558. R. R. (2000) Selective Rep-Cap gene amplification as a mechanism for high-titer recombinant AAV production from stable cell lines. Mol. , 2, 394–403. O. C. (2007) Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8 þ T cells in mice.

J. , 338, 853–860. S. (2008) 25 years of HIV. Nature, 453, 289–290. , Corey, L. N. (2008) Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebocontrolled, test-of-concept trial. Lancet, 372, 1881–1893. 4 Lalvani, A. A. (2008) T cells and tuberculosis: beyond interferongamma. J. Infect. , 197, 941–943. D. R. (2008) Toward an AIDS vaccine. Science, 320, 760–764. T. C. (2004) CD4 þ Tcell depletion during all stages of 7 8 9 10 HIV disease occurs predominantly in the gastrointestinal tract.

The characteristic feature of the adeno-associated virus is a deficiency in replication, and thus its inability to multiply in unaffected cells. However, new AAV particles are successfully generated in the presence of selected proteins derived from the adenovirus genome [111], or other viruses such as HSV [112]. Although recombinant AAV (rAAV) vectors have been initially developed for gene replacement therapy, several characteristics have made these potential candidates for vaccine delivery [113]: (i) rAAV vectors are well tolerated; (ii) they fail to induce strong vector-directed inflammatory responses, although the induction of neutralizing antibodies has been described [114]; and (iii) rAAV vectors do not introduce any of their viral genes into the host cells.

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